Computational Modeling of Neural Circuit-Like Coupled Belousov-Zhabotinsky Reactions
نویسندگان
چکیده
Computational Modeling of Neural Circuit-Like Coupled Belousov-Zhabotinsky Reactions A thesis presented to the Interdepartmental Program in Neuroscience. Graduate School of Arts and Science Brandeis University Waltham, Massachusetts By Alexander Mitchell We seek to adapt simplified circuit models of neural central pattern generators (CPGs) for use in a system of chemical oscillators using the Belousov-Zhabotinsky reaction (BZ). The BZ reaction lends itself well to the analysis of these complex oscillators, as it shares a number of properties with model neurons. BZ produces periodic all-or-nothing spike-like behavior, this spike behavior can be induced or prevented by perturbations to the reaction mixture, and critically reactors can be chemically coupled to one another. Microreactors of BZ mixture can be coupled with either hollow channels for the diffusion of aqueous solution (activator coupling) or with PDMS-filled channels for bromine (inhibitor coupling). Using existing computational models for single BZ reactors, we constructed and tested various simple arrangements of wells and chemical couplings that resembled different CPGs from the crustacean stomatogastric ganglion, lamprey spinal cord movement, and others. Using MatLab, we simulated the dynamics of oscillations in these arrangements under different conditions that could be used to disrupt the circuit, such as the presence chemical gradients across channels, light exposure, and the physical dimensions and arrangement of the circuits themselves. We then used these conditions to control the frequency and phase relationships of BZ oscillators. We successfully constructed models for a number of potential circuits and characterized their behavior. We hope that this work will encourage future exploration into applying neuroscience models to further the growing field of BZ research.
منابع مشابه
Tutorial Review: Simulation of Oscillating Chemical Reactions Using Microsoft Excel Macros
Oscillating reactions are one of the most interesting topics in chemistry and analytical chemistry. Fluctuations in concentrations of one the reacting species (usually a reaction intermediate) create an oscillating chemical reaction. In oscillating systems, the reaction is far from thermodynamic equilibrium. In these systems, at least one autocatalytic step is required. Developing an instinctiv...
متن کاملAnalog Reaction-Diffusion Chip Imitating Belousov-Zhabotinsky Reaction with Hardware Oregonator Model
We introduce analog integrated circuits that imitate a typical model of a reaction diffusion system, called the Belousov-Zhabotinsky (BZ) reaction. The BZ reaction gives us many insights into developing new architectures based on a new computing paradigm such as in active wave computing. The analog unit circuit exhibits both excitatory and oscillatory behaviors with very stiff responses, as obs...
متن کاملShape- and size-dependent patterns in self-oscillating polymer gels†‡
Polymeric hydrogels that exhibit autonomous, coupled chemical and mechanical oscillations are a unique example of synthetic, active soft matter. Here, we explore the effects of gel aspect ratio and absolute dimensions on pattern formation in hydrogels undergoing the Belousov-Zhabotinsky (BZ) reaction. We synthesize and analyze N-isopropylacrylamide gels containing covalently bound BZ catalyst a...
متن کاملDynamics of a Discrete Brusselator Model: Escape to Infinity and Julia Set
We consider a discrete version of the Brusselator Model of the famous Belousov-Zhabotinsky reaction in chemistry. The original model is a reaction-diffusion equation and its discrete version is a coupled map lattice. We study the dynamics of the local map, which is a smooth map of the plane. We discuss the set of trajectories that escape to infinity as well as analyze the set of bounded traject...
متن کاملComplex organizing centers in groups of oscillatory particles.
We investigate the origin and evolution of spatiotemporal complexity in a system of locally coupled Belousov-Zhabotinsky chemical oscillators. Using a combination of high resolution microscopy and fine grain numerical modeling, we demonstrate that the behavior arises from an initial phase heterogeneity of the oscillators. This heterogeneity produces wave breaks in the system with the free ends ...
متن کامل